Natural Machine — nm-portal

RANGANATHAN LAB

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Create sequences with BioM3 Thermostabilize a protein

Tools & Pipelines

Mysca

Pipeline Prealign Preprocess Core Analysis Projection

SBM

Train Sample

BLAST

Identify

HMMER

Homolog search

Dataset builder

Build: annotation fields Build: legacy captions Parse: UniProtKB Parse: Pfam families Parse: Pfam members Parse: CSV / TSV table

ESMFold

Predict structure

Structure alignment

Align against a reference View superpositions

Projections

PCA t-SNE UMAP

BioM3

Embedding (legacy) Embed: text → z_t Embed: sequence → z_p Embed: text → z_c Embed: joint → all Generation (legacy) Generate: from prompt Generate: from embedding Finetune: generalized Generation Pipeline

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